Research projects in Information Technology

Seizure prediction algorithms will be developed using the one-of-a-kind ultra-long-term human intracranial EEG dataset obtained from the Neurovista Corporation clinical trial of their Seizure Advisory System, or data from other implantable or wearable devices. This involves consideration of both feature-based machine learning or data science approaches and neural mass parameter estimation approaches to classify the EEG and predict seizures. Recent approaches focus on critical slowing as a marker for seizure susceptability and the influence of brain rhythms.

Optimisation methods, such as mixed integer linear programming, have been very successful at decision-making for more than 50 years. Optimisation algorithms support basically every industry behind the scenes and the simplex algorithm is one of the top 10 most influential algorithms. Major success stories include rostering nurses in hospitals, managing chains of organ transplants, planning production levels for manufacturing, routing delivery trucks for transport, scheduling power stations and electricity grids, to name just a few.

Transport and logistics businesses today use a large fleet of trucks and vans to deliver packages widely across a city. Deciding which package should be loaded on to which vehicle and deciding which package should be prioritised are surprisingly difficult computational tasks. State-of-the-art high-performance algorithms are used to calculate routes for the vehicles in order to minimise costs and maximise efficiency.

Many machine learning (ML) approaches have been applied to biomedical data but without substantial applications due to the poor interpretability of models. Although ML approaches have shown promising results in building prediction models, they are typically data-centric, lack context, and work best for specific feature types. Interpretability is the ability of an ML model to identify the causal relationships among variables. It is crucial for uncovering new insights, justifying a model performance and ultimately building trust in users for further applications.

Rodent behavioural testing is the study of the neural mechanisms underlying emotions [1].  It is used in the study of almost all mental conditions, including PTSD [2], OCD [3] and autism [4].  For example, to measure anxiety, researchers may place a rodent in a large tub, record a top-down video and measure the time spent near the safety of walls [2]. These videos also contain rich information about behavioural patterns, but scoring this manually is time consuming.

Antimicrobial resistance (AMR) is one of the most significant and immediate threats to health in Australia and globally. We are working on harnessing new technologies such as artificial intelligence and next-generation sequencing and to improve the diagnosis, treatment and prevention of AMR infections.

The specific aims of this project are:

1. Rapidly identify AMR and predict treatment responses through use of genomics and machine learning in a clinical context.

This PhD project aims to mitigate the data scarcity of new NLP and Multimodal applications by developing novel active learning algorithms. In this project, the student will leverage large foundation models, such as ChatGPT and GPT4, incorporating the cutting-edge techniques in the other areas, such as reinforcement learning, causality and GFlowNets, to devise novel active learning algorithms for NLP and multimodal applications.

PhD Studentship Description:

Portable point of care medical devices have revolutionised the way in which people receive medical treatment. It can bring timely and adequate care to people in need but also opens up the opportunity to address the healthcare inequality for the rural and remote.

Machine learning has recently made significant progress for medical imaging applications including image segmentation, enhancement, and reconstruction.

Funded as an Australian Research Council Discovery Project, this research aims to develop highly novel physics-informed deep learning methods for Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) and applications in image reconstruction and data analysis.